Sino-swed Tongkang Bio-tech (shenzhen) Limited

Shenzhen University

Shenzhen Conjugenix Pharmaceutical Technology Company Limited

Ji Zhou

Hu Chen

Ellen He

Liwen Liang

Huijun Li

Li Dang

Zuosheng Li

Sven Isac Skog

Cong Fang

Peng Gao

Zhulin Wang

Guangyi Jin

Yajuan Cheng

Shuxian Tan

Senbo Liu

Junye Tan

Mian Qin

Sumei Ren

The present application provides a novel series of small molecular immune agonists of Toll-like receptor, having a structure represented by Formula I. The present application further provides use of the immune agonist for activating and amplifying immune cells and lymphocytes, and for preparing an immunomodulatory drug, an immune anti-tumor small molecule drug, and an immune anti-tumor macromolecular drug.

Immune agonists

Disclosed are the development of a recombinant chicken IgY monoclonal antibody and a recombinant chicken IgY single-chain variable fragment (scFv) antibody raised against human thymidine kinase 1 in mammalian cells and a preparation method and use thereof. A light chain of the scFv antibody includes an amino acid sequence shown in SEQ ID NO: 1, and a heavy chain of the scFv antibody includes an amino acid sequence shown in SEQ ID NO: 2.

Development of recombinant chicken IgY monoclonal antibody and scFv antibodies raised against human tymidine kinase 1 expressed in mammalian cells and use thereof

Disclosed are the expression of a recombinant chicken IgY scFv antibody and monoclonal antibody raised against human thymidine kinase 1 (hTK1) in prokaryotic cells and a preparation method and use thereof. The scFv antibody includes an amino acid sequence shown in SEQ ID NO: 1. The anti-hTK1 recombinant scFv antibody and monoclonal antibody have good immunoreactivity, high specificity and sensitivity, and are easy to separate and purify.

Development of recombinant chicken IGY SCFV antibody raised against human thymidine kinase 1 expressed in prokaryotic cells and use thereof

Growing community of inventors

Guangdong, China

Ji Zhou