Hanmi Pharm. Co., Ltd.

Hanmi Science Co., Ltd.

Ji Young Jeon

Tae Hee Ha

Eun Joo Kwak

Kwee Hyun Suh

Maeng Sup Kim

Seok Jong Kang

Mi Young Cha

Kwang Ok Lee

Ju Yeon Lee

Mi Ra Kim

Myoung Gi Jo

Sun Young Jang

Hee Sook Oh

Hee Seok Kim

Jae Hyuk Jung

Jong Ouk Baek

Sun Hoe Lee

A novel fused pyrimidine based sulfonamide derivative represented by Formula I, a solvate thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including the same as an active ingredient are disclosed. The novel fused pyrimidine based sulfonamide derivative can effectively suppress the growth of cancer cells and resistance to drugs, which are induced by mutations in the tyrosine kinase domain of epidermal growth factor receptors, or the growth of cancer cells having such resistance.

Sulfonamide derivative with fused pyrimidine skeleton, having epidermal growth factor receptor mutation inhibitory effect

Provided are crystalline forms of acid addition salts of N-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)furo[3,2-d]pyrimidin-4-yloxy)phenyl)acrylamide, and a pharmaceutical composition including the same. The crystalline forms may be easily used in preparing the pharmaceutical composition including the same as an active ingredient.

Crystal form of acid addition salt of furopyrimidine compound

A crystalline form of an alkyl benzene sulfonyl urea compound that is useful as an oral antidiabetics is disclosed. Specifically, the compound is a hydrochloride salt of N-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-yloxy)phenyl)acrylamide of the following formula I. A pharmaceutical composition containing the compound is also disclosed: 

Crystalline forms of hydrochloride salts of thienopyrimidine compound

The present invention relates to a novel fused pyrimidine derivative having an inhibitory activity for tyrosine kinases, and a pharmaceutical composition for preventing or treating cancers, tumors, inflammatory diseases, autoimmune diseases, or immunologically mediated diseases comprising same as an active ingredient.

Fused pyrimidine derivatives for inhibition of tyrosine kinase activity

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Hwaseong-si, South Korea

Ji Young Jeon