Euro-celtique S.a.

Dov Pharmaceutical, Inc.

Ji Yang

Donald Kyle

Qun Sun

Phong X Nguyen

Derk J Hogenkamp

Parviz Gharagozloo

Laykea Tafesse

Xiaoming Zhou

Zhengming Chen

Phil Skolnick

John William Frank Whitehead

Khondaker Islam

The invention provides novel arylbicyclo[3.1.0]hexylamines, and related processes and intermediates for preparing these compounds, as well as compositions and methods employing these compounds for the treatment and/or prevention of central nervous system (CNS) disorders, including but not limited to depression and anxiety.

Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use

This invention relates aryl substituted thiazolidinones of Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein Rand R, are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

Aryl substituted thiazolidinones and the use thereof

This invention relates to compounds having the Formula I:or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R-Rare set in the specification. The invention also is directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

Aryl substituted pyrazoles, triazoles, and tetrazoles, and the use thereof

Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof

A compound of formula(wherein A, R, R, R, m and n are disclosed herein) or a pharmaceutically acceptable salt thereof (a 'Piperazine Compound'); pharmaceutical compositions comprising a Piperazine Compound; and methods for treating pain, urinary incontinence (UI), an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia and depression in an animal comprising administering to an animal in need thereof an effective amount of a Piperazine Compound are disclosed.

Therapeutic agents useful for treating pain

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Princeton Junction, NJ, United States of America

Ji Yang