Korea Research Institute of Bioscience and Biotechnology

Ji Won Ahn

Young Il Yeom

Hee Gu Lee

Eun Young Song

Mi Sun Won

Kyung Sook Chung

Hyang Sook Yoo

Jae Hun Cheong

Jeong Hae Choi

Chang Mo Kang

Disclosed are novel GPCR (G Protein Coupled Receptor) proteins and genes encoding the same. Also provided is the use of the proteins and the genes. Particularly, contemplated are a novel GPCR (G Protein Coupled Receptor) polypeptide, a polynucleotide coding for the same, a recombinant vector carrying the polynucleotide or a fragment thereof, host cells transformed with the vector, a transgenic animal infected with the vector. Also, a composition for detecting a cancer marker, comprising an agent capable of measuring the expression level of mRNA or protein of the GPCR polynucleotide, a kit for the diagnosis of cancer, comprising the composition, and a method for detecting the GPCR polypeptide and a gene encoding the polypeptide are provided. Further, a composition for the treatment and prevention of cancer, comprising an oligonucleotide inhibiting the expression of a gene encoding the GPCR polypeptide or an antibody against the GPCR protein, and a method for screening a modulator of the GPCR protein or a cancer therapeutic agent are provided.

G protein coupled receptor protein and use thereof

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Nonsan-si, South Korea

Ji Won Ahn