Array Biopharma Inc.

Ventirx Pharmaceuticals, Inc.

Ji-Long Jiang

J Jeffry Howbert

Hong Woon Yang

Venkat Kusukuntla

Pavel Krasik

Alexander Tretyakov

Nathan Nielsen

The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.

Methods of synthesis of benzazepine derivatives

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Toronto, Canada

Ji-Long Jiang