Korea Institute of Science and Technology

Ji Hyun Choi

Hee Sup Shin

Guk Bae Kim

Klaus Peter Koch

Disclosed are a novel, elastic, biocompatible, micro-sized, polyimide-based multi-channel microelectrode for recording of electroencephalography (EEG) from a laboratory animal including mouse, and a method for recording of laboratory animal EEG using the microelectrode. The microelectrode may include 2 grounding electrodes and 32 recording electrodes. A connector for signal transmission easily connects the microelectrode to a signal acquiring apparatus. The total weight of the microelectrode, including the connector, does not exceed 150 mg. Laboratory animal EEG, including that of mouse, provides the advantage of monitoring the brain state of a freely moving animal following a genetic or pharmaceutical manipulation. The microelectrode can be implanted without surgery and may be detached from wires while EEG is not recorded from the laboratory animal. The microelectrode can successfully acquire broadband EEG signals from the skull of the laboratory animal and is effective in monitoring spatial and temporal pattern of brain activities of the laboratory animal.

Flexible, multi-channel microelectrode for recording laboratory animal EEG and method for recording laboratory animal EEG using the same

Disclosed is an apparatus for stimulating the brain and measuring the light induced neuronal activity including a signal application unit which applies a signal to a living tissue to stimulate the neuronal cells in the living tissue; an electrode unit which detects an electrophysiological signal of the neuronal cell in response to the signal; and an insulation unit which controls an impedance of the electrode unit. The signal application unit is formed integrally with the electrode unit, so that the site where the signal is applied to the living tissue is approximated to the site where the response to the stimulation is measured.

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Hwaseong-si, South Korea

Ji Hyun Choi