Yipcell Inc.

Bifido Co., Ltd.

The Catholic University of Korea

Ji Hyeon Ju

Yoo Jun Nam

Sang Jun Park

Ji Won Kim

Sung Hwan Park

Yun Ju Jeong

Mi La Cho

Geun Eog Ji

Seung Ki Kwok

Jun Geol Ryu

Joo Yeon Jhun

Seon Yeong Lee

Su Young Yang

Ye Ri Rim

Yeri Rim

Hyon Ha Lee

Jae Yoon Ryu

Joo Ha Lee

A method for preparing chondrocyte pellets including: (a) culturing human induced pluripotent stem cells so as to form and obtain embryoid bodies; (b) inducing the embryonic bodies obtained in step (a) to become outgrowth cells and isolating same; and (c) culturing the outgrowth cells isolated in step (b) in a pellet form. A pharmaceutical composition including the chondrocyte pellets prepared by the preparation method; or a method for preventing or treating arthritis, including administering the chondrocyte pellets prepared by the method to an arthritis patient. Chondrocyte pellets of the present invention have a remarkably high rate of differentiation into chondrocytes, uniform size, and a homogeneous differentiation degree, and a pharmaceutical composition, including the pellets, has excellent cartilage regeneration effects at the site of cartilage damage, and is in injectable form, which does not require surgery, such that pain is relieved and a continuous arthritis treatment is provided.

Method for preparing pellets of chondrocytes from human induced pluripotent stem cells, and use thereof

The present invention relates to a method for inducing differentiation, into chondrocytes, of cord blood mononuclear cell-derived induced pluripotent stem cells. In a case where a chondrogenic pellet produced by the method of the present invention is transplanted into a cartilage damage area in vivo, regeneration of cartilage can be effectively exhibited by differentiated chondrocytes. In such a case, an effective cartilage regeneration capacity can be exhibited as compared with a case where chondrocytes produced by differentiation induction with the addition of a recombinant growth factor are transplanted. Thus, the present invention can be usefully used for tissue engineering therapies.

Method for producing cartilage cells induced to be differentiated from stem cells

Disclosed are a novelRAPO (Accession No.: KCTC 13773BP) and a composition for alleviating, treating or preventing rheumatoid arthritis containingRAPO (Accession No.: KCTC 13773BP) selected herein.

RAPO strain for alleviating, treating or preventing rheumatoid arthritis and composition containing the same

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Seoul, South Korea

Ji Hyeon Ju