Postech Academy-industry Foundation

Electronics and Telecommunications Research Institute

Ji Ho Yoo

Jin Woong Kim

Min Soo Kim

Kyeong Ok Kang

Sung Ho Ryu

In Seon Jang

Jun Ho Chung

Kyung Lock Kim

Su Min Yoon

Seung Jin Choi

Hyun Soo Cho

Yoon Sup Choi

Sang Uk Kim

The present invention relates to a method for preparing a target-specific non-antibody protein, and more particularly, to a method for preparing a target-specific non-antibody protein comprising the steps of: selecting non-antibody proteins having a structural complementarity with the target site of a target protein in a non-antibody protein library; calculating a binding energy of the selected non-antibody protein and the target protein; selecting a non-antibody protein having a favorable binding energy among the selected non-antibody proteins; selecting amino acid residues having a high binding energy among the interfacial amino acid residues of the selected non-antibody protein and the target protein; and substituting the selected amino acid residues with the amino acid residues having a low binding energy. In addition, the present invention relates to a target-specific non-antibody specifically binding with EGFR (Epidermal Growth Factor Receptor) domain 2, which is prepared by the method, and a cancer therapeutic composition comprising the same.

Target-specific non-antibody protein and method for preparing the same

A method and apparatus for separating and extracting main sound sources from a mixed musical sound signal are provided. A musical sound source separation apparatus may include an prior information signal compressor to compress an prior information signal including a characteristic of a predetermined sound source, a mixed signal divider to divide a mixed signal including a plurality of sound sources into a plurality of segments, a Nonnegative Matrix Partial Co-Factorization (NMPCF) analyzer to acquire common information shared by the plurality of segments, by applying an NMPCF algorithm to the prior information signal, and a target musical instrument signal separator to separate a target musical instrument signal corresponding to the predetermined sound source from the mixed signal, based on the common information.

Method and apparatus for separating musical sound source using time and frequency characteristics

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Seoul, South Korea

Ji Ho Yoo