Boston Biomedical, Inc.

Ji-Feng Liu

Chiang Jia Li

Wei Li

Harry Rogoff

Youzhi Li

Amanda Gibeau

Henry Rogoff

Compounds as inhibitors of CSCPK and related kinases. The compounds are thiazole-substituted indolin-2-ones and are prepared from indolin-2-ones. They are included in pharmaceutical compositions and both the compounds and the pharmaceutical compositions are used in inhibiting cancer stem cells and in the treatment of a protean kinase related disorders.

Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases

The invention provides novel inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal, and methods of making such compounds and compositions.

Inhibitors of kinases and cancer stem cells, and methods of preparation and use thereof

The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof.

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Winchester, MA, United States of America

Ji-Feng Liu