The Cleveland Clinic Foundation

Edwards Lifesciences Corporation

Other

Parker-hannifin Corporation

Ji-Feng Chen

Jose L Navia

Shengqiang Gao

Brian L Davis

Francis A Papay

Samantha Stucke

Rafi Avitsian

Andrew Michael Zura

Michael A Vogelbaum

Qun Zhou

Jose Antonio Navia

Jay Yadav

Patrick M McCarthy

William A Smith

Hitinder S Gurm

David J Horvath

Jorge Jordana

Robert B Guthrie

Michael Collinson

Tofy Mussivand

Kevin Day

Kent Wika

Andrew Zura

A method for replacing a native atrioventricular heart valve includes inserting a delivery catheter into the heart with a prosthetic apparatus retained in a compressed state inside of the delivery catheter. The prosthetic apparatus includes an annular anchoring member having a mesh structure made of Nitinol and defining a plurality of circumferentially extending rows of cells. A fabric layer is attached to an inner surface of the anchoring member. An annular support member made of Nitinol is disposed within the anchoring member. The support member is attached to the anchoring member with sutures. A prosthetic valve made of biological tissue is disposed within and secured to the support member. The method further includes allowing the prosthetic apparatus to self-expand to a radially expanded state in which the anchoring member contacts tissue of the native atrioventricular valve.

Apparatus and method for replacing a diseased cardiac valve

An apparatus is provided for replacing a native cardiac valve. The native cardiac valve has at least one leaflet and is surrounded by a native cardiac valve annulus having superior and inferior aspects. The apparatus comprises a barbell-shaped, expandable anchoring member including first, second, and main body portions extending between the end portions. The main body portion includes a channel defined by inner and outer surfaces. Each of the first and second end portions has a diameter greater than the diameter of the main body portion. The first and second end portions are sized to respectively contact the superior and inferior aspects of the native cardiac valve annulus when the expandable anchoring member is in an expanded configuration. The apparatus also includes an expandable support member operably disposed within the main body portion of the expandable anchoring member, and a prosthetic cardiac valve secured within the expandable support member.

A method is provided for implanting a valve having at least one valve leaflet within the cardiovascular system of a subject. One step of the method includes preparing a substantially dehydrated bioprosthetic valve and then providing an expandable support member having oppositely disposed first and second ends and a main body portion extending between the ends. Next, the substantially dehydrated bioprosthetic valve is attached to the expandable support member so that the substantially dehydrated bioprosthetic valve is operably secured within the main body portion of the expandable support member. The expandable support member is then crimped into a compressed configuration and placed at a desired location within the cardiovascular system of the subject. Either before or after placement at the desired location, fluid or blood re-hydrates the substantially dehydrated bioprosthetic valve.

Method for implanting a cardiovascular valve

Implantable cardiovascular valve

An apparatus for replacing a diseased cardiac valve is movable from a radially collapsed configuration to a radially expanded configuration. The apparatus comprises an expandable support member and a prosthetic valve secured therein. The main body portion extends between first and second end portions and includes an outer circumferential surface, a circumferential axis extending about the circumferential surface, and a plurality of wing members spaced apart from one another by an expandable region. Each of the wing members includes first and second end portions and a flexible middle portion extending between the end portions. The second end portion is integrally formed with the uyimain body portion. The first end portion is adjacent the circumferential axis and substantially flush with the outer circumferential surface in the radially collapsed configuration. The first end portion extends substantially radial to the outer circumferential surface in the radially expanded configuration.

A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode.

System and method for wound healing

A medical device sheath that includes a relatively inelastic body having a proximal end longitudinally separated from a distal end and defining a first lumen, an aperture located at the proximal end in fluid communication with the lumen and configured to admit an elongate endoscope body into the first lumen, and a transparent tip located longitudinally adjacent to an endoscope lens when the elongate endoscope body is located within the first lumen. The endoscope sheath may also include an elongate secondary tube defining a secondary lumen. A method of using the medical device sheath is also described.

Medical device sheath

A catheter assembly comprises a first catheter including a wall with an inner surface at least partially defining a lumen. A second catheter is connected to the wall of the first catheter and is disposed outward of the inner surface of the wall. The second catheter is at least partially covered by a sheath portion of the first catheter. A first portion of the wall of the first catheter is made of a relatively low durometer elastomeric material and is relatively extensible. A second portion of the wall is formed of a relatively high durometer elastomeric material and is relatively inextensible.

Catheter assembly

A catheter assembly comprises a first catheter including a wall with an inner surface at least partially defining a lumen. A second catheter is connected to the wall of the first catheter and is disposed outward of the inner surface of the wall. The second catheter is at least partially covered by a sheath portion of the first catheter.

An apparatus is provided for delivering an implantable medical device to a diseased cardiac valve includes an elongated shank, a brace member, and a locking mechanism. The shank has a first end portion, a second end portion, and a first longitudinal axis extending between the end portions. The first end portion includes a rotatable annular lower support and a fixing member. The lower support includes an annular ring having oppositely disposed upper and lower surfaces and a plane extending radially between the upper and lower surfaces. The brace member includes a barrel portion operably connected to a drive system. The barrel portion includes a first end portion, a second end portion, and a second longitudinal axis extending between the end portions. The drive system includes a housing operably connected to an actuating handle. The locking mechanism is operably connected to the housing and the elongated shank.

Growing community of inventors

Lakewood, OH, United States of America

Ji-Feng Chen