Daebong Ls Co., Ltd.

Korea Food Research Institute

Nanotech Ceramics Co., Ltd.

Korea Institute of Footwear Leather Technology

Ji Eun Lee

Jin Oh Park

Eun Ju Park

Hyun Ji

Young Min Kim

Hak Jong Choi

Dong Hun Han

Seul Ki Lim

Kyung Man Choi

Young Joon Oh

Min Sung Kwon

Ja Young Jang

A solid dispersion of amorphous efinaconazole and a method for preparing the same are proposed. The solid dispersion includes an amorphous form of efinaconazole and at least one stabilization carrier selected from hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), ethyl cellulose (EC), hydroxypropyl methylcellulose acetate succinate (HPMC-AS), polyvinylpyrrolidone (PVP), polyacrylic acid (PAA), saccharin, and malonic acid. The solid dispersion undergoes minimal thermodynamic deformation when exposed to ambient temperature and humidity, achieving improved stability, while maintaining the inherent improved stability and bioavailability of amorphous efinaconazole.

Amorphous efinaconazole solid dispersion

The present invention relates to a novel method for preparing efinaconazole using an ionic liquid as a medium. The method includes subjecting 1-[[(2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole to a coupling reaction with 4-methylenepiperidine or an organic chemically acceptable salt thereof in the presence of a base and an ionic liquid compound. The base makes the 4-methylenepiperidine or organic chemically acceptable salt thereof anionic. The use of the ionic liquid in the method of the present invention prevents the formation of related substances, shortens the reaction time, and enables easy preparation of the final compound efinaconazole in high purity and yield on a large scale, compared to the use of organic solvents in conventional methods.

Method for preparing efinaconazole using ionic liquid as medium

The present disclosure relates to novelWIKIM55 isolated from kimchi, and a composition containing the same. TheWIKIM55 according to the present disclosure is a probiotic having activities of promoting hair growth and can be diversely applied for intestinal regulation and promotion of hair growth in humans or animals.

WIKIM55 having activity of promoting hair growth, and composition containing same

Disclosed are a climbing shoes outsole with good adhesive and non-slip properties and a method for manufacturing the same. More specifically, the climbing shoes outsole comprises a butyl rubber layer formed at a side of the outsole in contact with the ground, and a general-purpose rubber layer laminated on the butyl rubber layer.

Climbing shoes outsole having good adhesive and non-slip properties and method for manufacturing thereof

Growing community of inventors

Busan, South Korea

Ji Eun Lee