Daewoong Pharmaceutical Co., Ltd.

Korea Research Institute of Bioscience and Biotechnology

Daewoong Co., Ltd.

In Therapeutics

Ji Duck Kim

In Woo Kim

Jun Hee Lee

Mi Ryeong Han

Sun Ah Jun

Hong-Chul Yoon

Hyae Jung Hyun

Joon Seok Park

Kyung A Yu

Sang Shin Lee

Min Hee Cho

In Young Lee

Deok Ki Eom

Hong Chul Yoon

Yeon Im Lee

Yun Soo Yoon

Hyo Shin Kim

Ji Sung Yoon

Inwoo Kim

Min Jae Cho

Ha Nee Seo

Yun Soo Na

Hyung Geun Lee

Yung Hee Kho

Sang Bae Han

Jin Ha Lee

Hyung-Geun Lee

Hwan Mook Kim

Sang Ho Lee

Sun Young Kim

Ha Young Kim

Bum Woo Park

Gyoon Hee Han

Soo Jin Choi

Chun Ho Lee

Jeom Yong Kim

Joon Hwan Lee

Youn Jung Yoon

Ja Kyung Yoo

Chang Woo Lee

Chang Min Park

Song Kyu Park

Nam Youn Kim

Hee Kyoon Yoon

Ho Bin Lee

Ki Hoon Lee

Hee Yoon Lee

Byung Goo Lee

Myunggi Jung

Seong Hee Cho

Jakyung Yoo

Jin Hyuk Yang

Dong Kyu Ryu

Sang Hyun Nam

Tae Gyu Chun

Bong Yong Lee

Hye Ryun Shin

Hyang Woo Lee

Yeon Jung Park

Eunkyung Park

Kwon Jo Lim

Jeung Whan Han

Kyunga Yu

Kyung Ha Chung

Yong Kee Kim

Eun Kyung Park

Yun Ju Oh

Young Mook Lim

The present invention relates to a compound represented by the Chemical Formula 1 defined in the present specification, or a pharmaceutically acceptable salt thereof. The compound according to the present invention can be usefully used for the prevention or treatment of diseases which are associated with kinase inhibitory actions. 

Substituted pyrrolo[2,1-f][1,2,4]triazines as kinase inhibitors

The present invention relates to a pyrazolopyrimidine derivative, or a pharmaceutically acceptable salt thereof. The compound according to the present invention can be usefully used for the prevention or treatment of diseases which are associated with kinase inhibitory actions.

Pyrazolopyrimidine derivatives as kinase inhibitor

The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and use thereof. The compound represented by the Formula 1 or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof can be effectively used in the prevention or treatment of pains, for example, acute pain, chronic pain, pain from nervous disease, postoperative pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, paroxysmal extreme pain disorder (PEPD).

Sodium channel blockers

The present invention provides tetrahydrocyclopentapyrrole derivatives that can be used for preventing or treating peptic ulcer, gastritis or reflux esophagitis, a method for preparing the same, and a pharmaceutical composition containing the same.

Tetrahydrocyclopentapyrrole derivatives and a method for preparing the same

Disclosed are a sulfonylindole derivative useful for the prevention or treatment of peptic ulcer, gastritis or reflux esophagitis, a method of preparing the same, and a pharmaceutical composition containing the same.

Sulfonylindole derivatives and method for preparing the same

The present invention relates to novel oxodihydropyridinecarbohydrazide derivatives with excellent antifungal activities, an antifungal composition containing the same, and its use for the prevention and treatment of fungal infectious diseases. The oxodihydropyridinecarbohydrazide derivatives of the present invention have excellent antifungal and fungicidal activities, and thus will be useful for the prevention and treatment of various fungal infections byspp.,spp.,andspp., etc. Additionally, the oxodihydropyridinecarbohydrazide derivatives of the present invention, unlike other fungicidal preparations, can be orally administered.

Antifungal oxodihydropyridinecarbohydrazide derivative

The present invention relates to a compound having a blocking effect against sodium ion channels, particularly Nav1.7, a preparation method thereof and the use thereof. A compound represented by formula 1 according to the invention, or a pharmaceutically acceptable salt, hydrate, solvate or isomer thereof may be effectively used for the prevention or treatment of pain, for example, acute pain, chronic pain, neuropathic pain, post-surgery pain, migraine, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neuropathic disease, epilepsy, arrhythmia, myotonia, ataxia, multiple sclerosis, irritable bowel syndrome, urinary incontinence, visceral pain, depression, erythromelalgia, or paroxysmal extreme pain disorder (PEPD).

Sodium channel blockers, preparation method thereof and use thereof

Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

Benzoimidazole derivatives and pharmaceutical composition comprising the same

This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.

Method of preparing benzoimidazole derivatives

Disclosed are novel triazole derivatives. Exhibiting excellent antifungal activity and in vivo safety, they are useful for the treatment or prevention of fungal infections caused by a wide spectrum of fungi.

Antifungal triazole derivatives

Disclosed are biaryl benzoimidazole derivatives. They have an inhibitory effect on calcium influx in HEK cells, thereby showing a powerful antagonistic effect on a vanilloid receptor, and further have an analgesic effect, thereby being useful for preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, irritable bowel syndrome, a respiratory disorder such as cough, asthma, and chronic obstructive pulmonary disease, burning, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

Biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same

Disclosed are biaryl benzoimidazo derivatives. They have an inhibitory effect on calcium influx in HEK cells, thereby showing a powerful antagonistic effect on a vanilloid receptor, and further have an analgesic effect, thereby being useful for preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, irritable bowel syndrome, a respiratory disorder such as cough, asthma, and chronic obstructive pulmonary disease, burning, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.

Biaryl benzolmidazole derivatives and pharmaceutical composition comprising the same

The present invention relates to a novel benzoxazine benzimidazole derivative of formula (1) as an antagonist against a vanilloid receptor-1, a pharmaceutical composition comprising the same as an active ingredient, and a use thereof. The benzoxazine benzimidazole derivative of the present invention may be useful for preventing or treating a disease associated with antagonistic activity of vanilloid receptor-1: 

Benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof

Discloses is a benzoxazine benzimidazole derivative, represented by Chemical Formula 1, functioning as an antagonist to the vanilloid receptor-1, a pharmaceutical composition comprising the same, and the use thereof. The benzoxazine benzimidazole derivative can be useful for preventing or treating a disease associated with antagonistic activity of vanilloid receptor-1, without hyperthermia: wherein, R, R, R, Rand Rare as defined in the specification.

Pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof

The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the cancer disease comprising lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer or cancer of the anal region, stomach cancer, colon cancer, breast cancer, gynecologic tumors, Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphonas, cancer of the bladder, cancer of the kidney or ureter, or neoplasms of the central nervous system, therefore, it can be used as the therapeutics for treating and preventing cancer diseases.

2-oxo-heterocyclic compounds and pharmaceutical compositions

Growing community of inventors

Gyeonggi-do, South Korea

Ji Duck Kim