Mayo Foundation for Medical Education and Research

US Government As Represented by the Secretary of the Army

U.S. Army Medical Research and Material Command

Jewn Giew Park

Yuan-Ping Pang

James J Schmidt

Charles B Millard

Rajesh K Mishra

Jing Tang

Jon Davis

Shaohua Wang

Anuradha Vummenthala

Small-molecule inhibitors of Botulinum toxin, including BoNTA, BoNTD and BoNTE are provided, as well as methods of using the inhibitors.

Small-molecule botulinum toxin inhibitors

This disclosure relates to materials and methods for inhibiting Botulinum neurotoxin, and more particularly to materials and methods for inhibiting the zinc endopeptidase of Botulinum neurotoxin serotypes A, D and/or E (BoNTA, BoNTD and/or BoNTE).

Disclosed are efficient methods for loading amino derivatives onto trityl chloride resins and for cleaving chemically modified amino derivatives from trityl chloride resins. Methods for making a library of discrete chemically modified amino derivatives also disclosed.

Efficient methods for solid phase synthesis using trityl chloride resins

Growing community of inventors

Rochester, MN, United States of America

Jewn Giew Park