Grifols, S.a.

Jesus Fernandez Rodriguez

Pere Ristol Debart

Juan Ignacio Jorquera Nieto

Isabel Bravo Camison

Rafael Lopez Gomez

Isabel Brava Camison

The stable thrombin composition comprises purified thrombin, human albumin and a neutral salt, the resulting product being stable when stored as a lyophilisate or frozen and is adjusted to a nominal strength of 500 IU of thrombin or more per ml of solution, the human albumin being in a concentration of over 0.05% (w/v) and preferably between 0.1% (w/v) and 1% (w/v).

Process to prepare a stable thrombin composition

A process for removing viruses in fibrinogen solutions and fibrinogen obtained thereof wherein the process starts with an adjusted purified fibrinogen solution, the adjusted purified solution is frozen and then thawed at a temperature between 5 and 20&#xb0; C., the undissolved materials associated with the fibrinogen are subsequently separated, the temperature is adjusted and the resultant solution is finally subjected to nanofiltration using filters having a pore size smaller than 35 nm.

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Gava, Spain

Jesus Fernandez Rodriguez