Eli Lilly and Company

Université Louis Pasteur

Lilly, Sa

Jesus Ezquerra Carrera

Concepcion Pedregal Tercero

James E Audia

Stephen Richard Baker

Carlos Lamas Peteira

Camille-Georges Wermuth

Darryle D Schoepp

Almudena Rubio Esteban

Andr E Mann

Ang Ele Schoenfelder

The present invention provides novel tetrahydro-beta-carboline compounds having useful central nervous system activity. Further, there is provided tetrahydro-beta-carboline related compounds which are useful intermediates and have beneficial central nervous system activity. The invention provides formulations and methods for using the novel tetrahydro-beta-carboline and related compounds. Such compounds are particularly useful for the modulation of a 5-HT.sub.2B receptor.

Aminoalkyl-indoles

Tetrahydro-Beta-Carbolines

Tetrahydro-beta-carbolines

Disclosed herein is a method of treating a disease of the central nervous system with a compound of the formula ##STR1## in which m is 0, 1 or 2, n and q are each 0 or 1 to 5, and p is 0 or 1, X is --CO.sub.2 H or tetrazolyl,

Pharmaceutical compounds for the treatment of CNS diseases

Tetrahydro-beta carbolines

A pharmaceutical compound of the formula ##STR1## in which m is 0, 1 or 2, n and q are each 0 or 1 to 5, and p is 0 or 1, X is --CO.sub.2 H or tetrazolyl,

Pharmaceutical compounds

Growing community of inventors

Madrid, Spain

Jesus Ezquerra Carrera