Vertex Pharmaceuticals (San Diego) LLC

University of California

Vertex Pharmaceuticals, Inc.

Other

Jesus E Gonzalez, Iii

Michael P Maher

Roger Y Tsien

Andreas Peter Termin

Dean Wilson

Esther Martinborough

Yulian Zhang

Nicole Zimmerman

Timothy Donald Neubert

Roger D Tung

Lev T D Fanning

Nicole Zimmermann

Lev Tyler Dewey Fanning

Benjamin John Petzoldt

Jian Jim Wang

Peter D J Grootenhuis

Peter Diederik Jan Grootenhuis

A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.

Ion channel assay methods

Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.

High throughput method and system for screening candidate compounds for activity against target ion channels

The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Compositions useful as inhibitors of voltage-gated ion channels

The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Pyrimidines useful as modulators of voltage-gated ion channels

The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Quinazolines useful as modulators of ion channels

The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R, Z, Y, R, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.

Benzimidazoles useful as modulators of ion channels

Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises: Energy transfer is typically measured by fluorescence resonance energy transfer. In some embodiments the first and second reagents are bound together by a suitable linker. In one aspect the method is used to identify compounds which modulate membrane potentials in biological membranes.

Detection of transmembrane potentials by optical methods

Compositions useful as inhibitors of voltage-gated sodium channels

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San Diego, CA, United States of America

Jesus E Gonzalez, Iii