Luminex Corporation

Cepheid Corporation

Visby Medical, Inc.

Click Diagnostics, Inc.

Genturadx, Inc.

Progentech Limited

Other

Ceoheid

Accel Biotech, Inc.

Jesus Ching

Genturadx-usa, Inc.

Dylan Hilmer Bird

Bruce Richardson

Keith E. Moravick

Bruce A. Johnson

Phillip You Fai Lee

Ronald G Chang

David Hsiang Hu

Steve Jia Chang Yu

William A McMillan

Farzad Pourahmadi

Keith Edward Moravick

M Allen Northrup

Kurt Edward Petersen

Victor Briones

Gregory Loney

David Swenson

Adam De La Zerda

Brian Ciopyk

Boris Andreyev

Helen Huang

Steven Chu

Colin Kelly

Gregory T A Kovacs

Lee Allan Christel

Michael T Taylor

Phillip Belgrader

Bruce J Richardson

Stanley H Sakai

Douglas Bryan Dority

Bruce A Johnson

Keith E Moravick

Reuel Van Atta

Jian Ping Zhang

Jonathan Hong

James Jian Quan Wang

Wendy Wong

Kendra Lara Paul

Valeria Revilla

Adrienne C Lam

Steve Jia Yu

Shaunak Roy

Ryan Cena

Phoebe Cao

Philip Belgrader

Phillip You Lee

Jennifer Albrecht

Edward Biba

Douglas P Dority

Petersen E Kurt

Northrup M Allen

Gregory Ta Kovacs

Christel A Lee

Danielle McSheery

Rajinder K Bhatia

Kurt E Peterson

Wendy Wingkei Wong

Steve Chu

James Jian Wang

A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.

Devices and methods for molecular diagnostic testing

Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).

Devices and methods for nucleic acid extraction

A method includes conveying a detection solution containing a target amplicon into a detection module of a molecular diagnostic test device. The detection module includes a detection surface including a series of capture probes to which a first portion of the target amplicon is bound when the detection solution is conveyed. A first reagent formulated to produce a visible signal indicating a presence of the target amplicon is then conveyed into the detection module. The first reagent is bound to a second portion of the target amplicon when the first reagent is conveyed. A second reagent is conveyed into the detection module. The second reagent includes a precipitating substrate formulated to catalyze the production of the visible signal by producing an insoluble colored product when the second reagent is in contact with the first reagent. The method includes viewing the visible signal via a transparent portion of the detection module.

Devices and methods for the detection of molecules using a flow cell

Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided, as are methods for using such cartridges. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.

Apparatus and methods for integrated sample preparation, reaction and detection

Apparatuses for preparing a sample are disclosed herein. The apparatuses include a chamber, a first valve at least partially disposed in the first chamber, a second valve at least partially disposed in the first chamber, and a pump comprising an actuator and nozzle.

Cassette for sample preparation

A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and direction system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.

Instrument for cassette for sample preparation

A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor driving system, a close-loop heater control and detection system, a magnetic particle transfer system, a reagent release system, a reagent pre-mix pumping system and a wash buffer pumping system.

Growing community of inventors

San Jose, CA, United States of America

Jesus Ching