Janssen Pharmaceutica Nv

Jesus Alcazar

Michael K Ameriks

Pablo Garcia-Reynaga

Andrew V Samant

Cynthia B Berry

J A Vega-Ramiro

Brian Ngo Laforteza

Azaspirocycle compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, bipolar disorder), cancers and eye conditions: wherein X, R, R, R, R, m, n, o, and p are defined herein.

Azaspirocycles as monoacylglycerol lipase modulators

Compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to depression, major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, and bipolar disorder), cancers and eye conditions: wherein R,, R, and L are as defined herein.

Cyclobutyl amide monoacylglycerol lipase modulators

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Toledo, Spain

Jesus Alcazar