Centro De Ingenieria Genetica Y Biotecnologia

Jesus A Del Valle Rosales

Alexis Musacchio Lasa

Vivian Morera Cordova

Anabel Alvarez Acosta

Lidia I Perez

Juan M Grillo

Selman H Sosa

Beatriz T Santos

Silva Rodriquez

Sonia G Blanco

Evelin C Menendez

Saturnino H Martinez

Julio R Maso

Edelgis C Rodriquez

Guillen Nieto

Silian C Leon

The present invention is concerned with a method for the isolation of a nucleotide sequence which codes for a protein having a molecular weight of about 64,000 daltons, which is located on the outer membrane of N. meningitidis, as well as with the recombinant DNA obtained therefrom, which is used for the transformation of a host microorganism. The technical object pursued with the invention is the identification of a nucleotide sequence coding for a highly conserved and common protein for the majority of pathogenic Neisseria strains, the production of this protein with a high level of purity and in commercially useful amounts using the recombinant way, so that it can be used in diagnostic methods and vaccine preparations with a broad immunoprotection spectrum.

Nucleotide sequence coding for an outer membrane protein from Neisseria

Growing community of inventors

Ciudad de la Habana, Cuba

Jesus A Del Valle Rosales