Myriad Genetics, Inc.

Jessymol Mathew

Masakatsu Eguchi

Hiroshi Nakanishi

Jan Urban

Min Sang Lee

Vincent Huber

Thomas Little

Danwen Huang

Marcin Stasiak

Maher Qabar

Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein Y, A, B, Rand Rare as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing the same, are neurokinin (tachykinin) antagonists. Libraries containing the compounds of this invention are also disclosed, as well as methods for screening such libraries to identify biologically active members.

Helix mimetics and composition and methods related thereto

Reverse-turn mimetics and methods relating to the same having the following structure are disclosed: including pharmaceutically acceptable salts and stereoisomers thereof, wherein R, R, Rand Rare as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing such compounds, are neurokinin (tachykinin) antagonists. Libraries containing the reverse-turn mimetics of this invention are also disclosed.

Reverse-turn mimetics and compositions and methods relating thereto

Compounds which mimic the secondary structure of helical regions of biologically active peptides and proteins having the following structure:including pharmaceutically acceptable salts and stereoisomers thereof, wherein Y, A, B, Rand Rare as defined herein. Such compounds have utility over a wide range of applications, including use as diagnostic and therapeutic agents. In particular, compounds of this invention, and pharmaceutical compositions containing the same, are neurokinin (tachykinin) antagonists. Libaries contaning the compounds of this invention are also disclosed, as well as methods for screening such libaries identify biologically active members.

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Cary, NC, United States of America

Jessymol Mathew