Schering Corporation

Tilos Therapeutics, Inc.

Merck Sharp + Dohme Corp.

Dana-farber-cancer Institute Inc.

Jessie M English

Paul Reichert

Alan W Hruza

Barbara S Fox

Shahriar Shane Taremi

Patricia Rao

Thomas E Hesson

Catherine Smith

Weihong Jin

Thierry Oliver Fischmann

Stavros Kopsiaftis

Randall Burton

Kenneth J Simon

Kwok-kin Wong

Renee Moore

Mark Bittinger

Xiufeng Song

Sima Zacharek

Provided herein are antibodies which bind to latency-associated peptide (LAP) of TGF-&#x3b2;1 and are characterized by particular functional features, such as binding specifically to LAP-TGF&#x3b2;1 on cells but not to LAP-TGF&#x3b2;1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.

Methods of using anti-lap antibodies

Provided herein are anti-LAP antibodies (e.g., recombinant humanized, chimeric, and human anti-LAP antibodies) or antigen binding fragments thereof which have therapeutically beneficial properties, such as binding specifically to LAP-TGF&#x3b2;1 on cells but not to LAP-TGF&#x3b2;1 in extracellular matrix, as well as compositions including the same. Also provided are uses of these antibodies or antigen binding fragments in therapeutic applications, such as in the treatment of cancer, and diagnostic applications.

Anti-lap antibody variants

The present invention is based, in part, on the identification, of novel mitochondrial iron-sulfur (Fe&#x2014;S) cluster biosynthesis pathway biomarkers and modulators, and methods of use thereof, for identifying, assessing, preventing, and treating cancer.

Compositions and methods for identification, assessment, prevention, and treatment of cancer using NFS1 biomarkers and modulators

The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design.

Methods for crystallizing ERK2 polypeptides

ERK2 crystals

Growing community of inventors

Cambridge, MA, United States of America

Jessie M English