Novartis Ag

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Jessie Gu

William J Pavan

Danilo A Tagle

Jill A Morris

Peter G Pentchev

Melissa A Ashlock

Stacie K Loftus

Eugene D Carstea

Muneto Mogi

Ken Yamada

Kazuhiko Nonomura

Hironobu Mitani

Tomoko Hayashi

Yoshie Arai

Margaret Elizabeth Brousseau

The present invention provides a compound of Formula I: for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride level; wherein R, X, R, R, C, L and p are defined herein. The present invention further provides a combination of pharmacologically active agents for use in the treatment, amelioration and/or prevention of diseases and conditions associated with CETP activity, such as atherosclerosis and dyslipidemia, in a subject with high triglyceride levels.

Method of treating atherosclerosis in high triglyceride subjects

The use of a MEK inhibitor compound of Formula (I), as defined herein, or a pharmaceutically acceptable salt thereof for the preparation of a medicament for the treatment of Noonan Syndrome, a method of treating a warm-blooded animal, especially a human, having Noonan Syndrome, comprising administering to said animal a therapeutically effective amount of a MEK inhibitor compound of Formula (I), as defined herein, or a pharmaceutically acceptable salt thereof; and to a pharmaceutical composition and a commercial package comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and a package insert or other labeling including directions for treating Noonan Syndrome.

Use of organic compound for the treatment of Noonan Syndrome

A gene for type C Niemann-Pick disease (NP-C) is disclosed, along with the amino acid sequence of the encoded peptide. Applications which are made possible by the present invention include detection of NP-C carriers and diagnosis of NP-C sufferers. The murine ortholog of the human gene is also disclosed.

Genes for Niemann-Pick type C disease

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Cambridge, MA, United States of America

Jessie Gu