Janssen Biotech, Inc.

Centocor Ortho Biotech Inc.

Jessica Schreiter

Jarrat Jordan

Chichi Huang

Robert T Sarisky

Bethany Swencki-Underwood

Marc Chevrier

Sun-Yung Jung

Matteo Cesaroni

Type I interferon (IFN-I) signatures are useful in methods of diagnosing whether a subject (or patient) with IFN-I mediated disease will be responsive to treatment with an IFN-I inhibitor and treating or refraining from treating the subjects.

Type I interferon signatures and methods of use

Agents interfering with translocation of Toll-like receptor 3 (TLR3), methods of making and using the foregoing are disclosed.

Methods for suppressing toll-like receptor activity

Cytokine IFN&#x3c9; nucleic acids from the Cynomolgus monkey are useful for expression of IFN&#x3c9; proteins that are functional homologs of human IFN&#x3c9;. The nucleic acids and proteins produced therefrom are useful in screening and safety testing of IFN&#x3c9;, the generation and testing of IFN&#x3c9; modulators and related activities.

Monkey homolog of human interferon omega

Isolated polynucleotides encodingToll-Like Receptor 3 (Baboon TLR3), polypeptides obtainable from expression of these polynucleotides, recombinant cells, and methods of use are disclosed.

Growing community of inventors

Radnor, PA, United States of America

Jessica Schreiter