Oxford Nanopore Technologies Limited

Jessica Mary May Johnson

Andrew John Heron

James White

James Anthony Clarke

Lakmal Nishantha Jayasinghe

Christopher James Wright

Mark Bruce

Rebecca Victoria Bowen

David Jackson Stoddart

Domenico Caprotti

Ramiz Iqbal Nathani

Richard Muscat

Paul Richard Moody

Mark John Bruce

Methods of characterizing an analyte using a detector such as a nanopore and an enzyme are provided. One aspect features methods for characterizing a double-stranded polynucleotide using a detector, e.g., without using a hairpin connecting a template and a complement of the double-stranded polynucleotide. Another aspect features methods for characterizing an analyte using a tag-modified nanopore with increased sensitivity and/or higher throughput. Compositions and systems including, e.g., adaptors for attachment to double-stranded polynucleotides and tag-modified nanopores, which can be used in the methods are also provided.

Method of characterizing a polynucleotide

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Oxford, United Kingdom

Jessica Mary May Johnson