National Institutes of Health, a Component of the US Dept. of Health & Human Services

University of Michigan

The University of Birmingham

Jessica J O'Konek

Douglas M Smith

James R Baker, Jr

Jay A Berzofsky

Gurdyal S Besra

Anna U Bielinska

Paul E Makidon

Masaki Terabe

Nicholas W Lukacs

Petr Illarionov

James R Baker

The present invention provides methods and compositions for the stimulation of immune responses and for treating or preventing allergic disease and responses and inflammatory disease and responses. In particular, the present invention provides nanoemulsion compositions and methods of using the same for the induction of immune responses that prevent or treat allergic disease by reducing allergic response. Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination)) and research applications.

Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease

&#x3b2;-mannosylceramides or salts or solvates thereof in a pharmaceutically acceptable carrier, for use as a Type I NKT cell agonist in conjunction with a therapeutically effective amount of &#x3b1;-galactosylceramide or a salt or a solvate thereof, and/or at least one or more T-cell co-stimulatory molecules, disclosed. Compositions comprising &#x3b2;-mannosylceramide, as well as methods of treatment of tumors are also provided.

Beta-mannosylceramide and stimulation of NKT cell anti-tumor immunity

&#x3b2;-mannosylceramide and stimulation of NKT cell anti-tumor immunity

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Ann Arbor, MI, United States of America

Jessica J O'Konek