Reva Medical, Inc.

Jessica Earley

Lioubov Kabalnova

Ernest G Baluca

Durgadas Bolikal

Robert K Schultz

Donald K Brandom

Elizabeth Nesseler

Ruth Sosa

Joann Yao

Methods, copolymer materials and devices are provided for embolic arterial interventions (embolization therapy or embolotherapy). More particularly, radiopaque, bioresorbable spherical microparticles for embolization or vascular occlusion therapies, comprising copolymers of iodine-containing, halogenated phenyl-containing units, such as iodinated desaminotyrosine derivatives, and rubbery components, such as polyethylene glycol (PEG), polycaprolactone (PCL), polytetramethylene oxide (PTMO) or polytrimethylene carbonate (PTMC), are provided. The provided microbeads may further contain, or be coated with, therapeutic agents such as paclitaxel, for targeted delivery of the therapeutics.

Porous bioresorbable radiopaque embolic microspheres for drug delivery

Methods of making multi-block copolymer that reduce the tendency for large phase domains to form provide copolymer compositions that are useful for various applications, including the manufacture of medical devices.

Multi-block copolymer compositions

The present application provides polymer materials having the desired properties for implantation into a human or animal body, in particular, biocompatibility, biodegradability, radiopacity and mechanical properties. Methods of making such polymer materials, compositions or devices comprising such polymer materials, and uses of such polymer materials, compositions and devices are also disclosed.

Cross-linked radiopaque bioresorbable polymers and devices made therefrom

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San Diego, CA, United States of America

Jessica Earley