University of Rochester

Jesse Schallek

Raul Andres Guevara-Torres

Aby Joseph

Keith Parkins

A method to image an in vivo object in an eye includes illuminating an object in the eye by a light source; configuring one or more detectors to receive light from a conjugate plane behind a confocal plane of the object, the conjugate plane acting as a light screen; receiving at the one or more detectors a backscattered light from the light source which has been refracted at least in part by the object before being backscattered from the light screen to provide a detector data; and processing the detector data over a time period by a computer to generate information about the object.

In vivo object identification, counting, and imaging based on light backscattered from a plane behind the object

A method for imaging vertebrate translucent retinal structures includes: imaging a translucent retinal structure at a first imaging plane in the retina with a light source focused at such first imaging plane, and detecting reflected light with a non-confocal off-axis detector, wherein the detector is axially displaced from a plane conjugate to the first imaging plane to a plane conjugate to a reflective layer deeper in the retina along a path of illumination from the light source.

Label-free contrast enhancement for translucent cell imaging by purposefully displacing the detector

An image processing method for determining and reporting a velocity of a plurality of objects in a space-time image includes: providing an imager to acquire a plurality of images of a line; receiving a plurality of images; generating a space-time image from the plurality of images of the line; applying a mask to a subset image of the space-time image to provide a masked subset area; generating a rotational look up table of intensity values of pixels of columns and rows of the masked subset area; generating a radon transform for each subset image; computing a velocity of a plurality of objects in the subset image based on the radon transform; repeating the step of applying a mask to the step of computing a velocity; and displaying the velocity of a plurality of objects overlaying the space-time image substantially in real-time as the plurality of images are acquired.

Rapid assessment and visual reporting of local particle velocity

An ophthalmic imaging system for imaging an axial and lateral point-spread of light distribution pattern of light reflected from a surface of an animal or human eye includes an ophthalmic imaging apparatus adapted to generate an illumination light of a surface of the eye. A detection arm includes a digital micromirror device (DMD) having an array of mirror facets. A first detector is disposed to receive a first portion of the axial and lateral point-spread of light distribution of light, and one or a plurality of additional detectors are disposed to receive a light from one or a plurality of different portions of the axial and lateral point-spread of light distribution pattern of light. A detection arm, a method for imaging axial and lateral point-spread of light distribution components, and a method for auto-centering a distribution pattern in an imaging plane of a DMD device are also described.

System and method for enhanced contrast imaging based on detection of different portions of a lateral point-spread of light pattern

A method for creating a virtual 2D image of an object moving in a blood vessel includes the steps of: providing an imaging apparatus capable of acquiring 1D images. The imaging apparatus is communicatively coupled to a computer. Multiple 1D images of a substantially fixed footprint on a surface of an organ are acquired over a period of time. A virtual 2D image showing the object moving in the blood vessel is formed by combining by computer the multiple 1D images. The virtual 2D image can be displayed and/or saved to a non-volatile memory. A system to perform the method is also described. Another method for creating a virtual 1D image of an object moving in a blood vessel is also described.

Growing community of inventors

Rush, NY, United States of America

Jesse Schallek