Gilead Sciences, Inc.

Carna Biosciences, Inc.

Jesse M Jacobsen

Leena Patel

Michael Graupe

Juan A Guerrero

Tetsuya Kobayashi

Suet Chung Yeung

Jie Xu

Yasamin Moazami

Heath A Weaver

Stephen D Holmbo

Jonathan William Medley

Julian Andrew Codelli

Kevin S Currie

Jennifer Anne Treiberg

Seung H Lee

Stephane Perreault

Jayaraman Chandrasekhar

Masaaki Sawa

Qingming Zhu

Patrick J Salvo

Hirokazu Matsumoto

Mai Arai

Ryoko Nakai

Catherine Pugh

Thomas J Paul

David L Kukla

Jonah J Chang

Will Watkins

Latesh Lad

Eric Hu

Provided herein is a compound of Formula I: or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, a pharmaceutical composition comprising a compound of the present invention, together with a pharmaceutically acceptable excipient thereof, and a method of treating cancer with the same.

PARP7 inhibitors

The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

Diacylglycerol kinase modulating compounds

Diacylglyercol kinase modulating compounds

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Seattle, WA, United States of America

Jesse M Jacobsen