Massachusetts Institute of Technology

Jesse Kirkpatrick

Sangeeta N Bhatia

Andrew Warren

Jaideep S Dudani

Colin Buss

Aspects of the present disclosure relate to methods and compositions useful for in vivo and/or in vitro profiling of proteases present in the lung. In some embodiments, the disclosure provides methods of in vivo enzymatic processing of exogenous molecules followed by detection of detectable markers as representative of the presence of active proteases associated with a lung disease, for example, lung cancer and lung infections. In some embodiments, the disclosure provides compositions and methods for production of a lung disease signature and diagnosis of lung disease.

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Cambridge, MA, United States of America

Jesse Kirkpatrick