Terumo Bct, Inc.

Terumo Kabushiki Kaisha

Jesse Janzen

James R Ladtkow

Andrew Gloor

Dennis J Hlavinka

Thomas J Felt

Taylor Polodna

Masatsugu Igarashi

Luke Edwin Ladtkow

Randy Peery

Kevin Klimek

Luke Edwin Storm

Provided is a centrifuge cassette assembly () for separating a fluid and related method of manufacture. The cassette assembly includes a first chamber, a second chamber (), a fluidic channel () creating a fluid connection between the first chamber and the second chamber, at least one molded insertion valve () configured to control the flow of fluid in the fluidic channel and a heating element () for actuating the at least one molded valve. Further provided are Normally Open Valves (NOVs) () and Normally Closed Valves (NCVs) () which are capable of insertion into, and which control the fluid flow of, the centrifuge cassette assembly.

Centrifugal cassette with molded insertable valves

A modular cassette is provided for separating a composite fluid into at least two component parts thereof during centrifugation. The modular cassette includes: a housing defining a fluid inlet, a fluid outlet, and a chamber for fluid separation; a fluidic channel configured to provide fluid communication between at least two components of the modular cassette; a heat expanding valve including: a flow pathway including undulations configured to facilitate closing of the fluidic channel, wherein the heat expanding valve occludes one or more of the undulations of the flow pathway to close the fluidic channel; and a heating element configured to actuate the heat expanding valve.

Centrifugal fluid separation device

A multi-tubing pinch valve assembly including a receiving space defined between a pinch protrusion and tubing contact body. The multi-tubing pinch valve assembly is moveable between a retracted state and an extended state. In the extended state, multiple tubes disposed in the receiving space are pinched, restricting flow therethrough. In the retracted state, multiple tubes are capable of being loaded into and/or out of the receiving space.

Multiple-tube pinch valve assembly

A modular cassette and method for separating a composite fluid into at least two component parts thereof during centrifugation is provided. The modular cassette includes a fluid inlet portion, at least one fluid separation portion, at least one media chamber in fluid communication with the fluid separation portion, a fluid collection portion, at least one fluidic channel configured to form a fluid communication between at least two components of the cassette, at least one wax valve including undulating flow channel portions configured to close at least one of the fluidic channels, and at least one heating element configured to actuate the at least one wax valve.

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Ft. Collins, CO, United States of America

Jesse Janzen