Avi Biopharma, Inc.

Sarepta Therapeutics, Inc.

Jesse D Deere

Patrick L Iversen

Bruce L Geller

Dwight D Weller

A method and antisense compound for inhibiting the growth of pathogenic bacterial cells are disclosed. The compound contains no more than 12 nucleotide bases and has a targeting nucleic acid sequence of no fewer than 10 bases in length that is complementary to a target sequence containing or within 10 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes a bacterial protein essential for bacterial replication. The compound binds to a target mRNA with a Tof between 50&#xb0; to 60&#xb0; C. The relatively short antisense compounds are substantially more active than conventional antisense compounds having a targeting base sequence of 15 or more bases.

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Davis, CA, United States of America

Jesse D Deere