Research Corporation Technologies, Inc.

Other

The United States of America As Represented by the Secretary of

Jesse Baumgold

Wayne D Bowen

Terry W Moody

Christy S John

John G McAfee

Kenneth Alan Jacobson

Barton J Bradbury

The invention describes generating and use of a multi-layer plasmonic slide, wherein the plasmonic slide comprises at least 6 layers of metallic nanoparticles that can enhance the detection of fluorescent signals and wherein the plasmonic slide can be printed as a microarray of any size. The microarray containing the plasmonic slide can further be printed with a protein, a glycan, or an antibody. The multi-layer plasmonic slide is capable of detecting proteins, polynucleotides, and/or glycans at orders of magnitude lower concentration than non-plasmonic substrates.

Microarray slides that enhance fluorescent signals via plasmonic interaction

The present invention relates to a class of compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, prostate carcinomas, breast carcinomas, malignant melanomas, gliomas, neuroblastomas and pheochromocytomas. The compounds of the present invention can also bind with high specificity to cell surface sigma receptors and can therefore be used for diagnostic imaging of any tissue having an abundance of cells with sigma receptors. The present invention provides such compounds as agents for diagnostic imaging and for detecting and treating tumors containing the cancer cells described above.

Compounds for cancer imaging and therapy

Benzamide compounds for cancer imaging and therapy

Benzamide compounds containing a heterocyclic ring for tumor imaging and

Methods for cancer imaging and therapy using benzamine compounds

Compounds, which are muscarinic agents, having the formula ##STR1## wherein Am is --N(R).sub.a).sub.2, --N(R.sub.a).sub.3.sup.+ I.sup.-, --N (CH.sub.2).sub.n', or ##STR2## n' is an integer from 2 to 7 and R.sub.a is an alkyl having 1 to 4 carbon atoms, and each R.sub.a may be the same or different wherein the other substituents are defined hereinbelow.

N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl]amide congeners as muscarinic

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Bethesda, MD, United States of America

Jesse Baumgold