University of Copenhagen

Curatis Ag

Rigshospitalet—glostrup

Head Explorer A/s

Head Explorer Aps

Jes Olesen

Lars Bendtsen

Rigmor Jensen

Ulf Madsen

Arnim Pause

Mirtazapine is useful for the treatment and/or prophylaxis of medication overuse headache based on tension-type headache. Moreover, a pharmaceutical composition and/or the use of mirtazapine for the manufacture of a medicament, are useful against medication overuse headache based on tension-type headache, and the treatment of medication overuse headache based on tension-type headache.

Mirtazapine for use in medication overuse headache based on tension-type headache

NMDA receptor antagonists, especially mirtazapine, can be used to treat tension-type headaches.

Treatment of tension-type headaches with NMDA receptor antagonists

Tension-type headache is treated by interacting with neuronal transmission in relation to pain in connection with headache in a way which prevents or decreases sensitization of second order nociceptive neurons. In particular, treatment is performed by administration of an effective amount of a substance which prevents or decreases central sensitization. Important examples of such substances are substances which interact with nitric oxide, such as nitric oxide synthase (NOS) inhibitors, such as L-NMMA or L-NAME or L-NIO or L-NNA. According to a broader aspect of the invention tension-type headache is treated by administration of substances which are effective in preventing or decreasing pain in connection with tension-type headache, such as the substances mentioned above. Accordingly, the invention relates to treatment of tension-type headache by administration of substances which substantially inhibit the activity of nitric oxide synthase (NOS), such as NOS inhibitors, such as L-NMMA or L-NAME or L-NIO or L-NNA.

Method for treating tension-type headache with inhibitors of nitric oxide and nitric oxide synthase

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Hellerup, Denmark

Jes Olesen