Centre National De La Recherche Scientifique

Universitë De Bordeaux

UniversitÉde Strasbourg

Institut Polytechnique De Bordeaux

Jerôme Wagner

Dominique Burnouf

Gilles Guichard

The present invention relates to a fusion peptide having one of the following formulae: P1-L-P2 (I) or P2-L-P1 (II) wherein P1 is chosen from the proline-rich antimicrobial peptides; Lisa peptide linker; and P2 has the following formula (III): wherein m is 0 or 1; n is an integer comprised between 0 and 9; p is an integer comprised between 0 and 10; r is 0, 1 or 2; s is 0 or 1; Gln is glutamine; Ris the side chain of arginine or lysine; Ris for example a —(CH)—C-cycloalkyl group optionally substituted; Ris for example a C-alkyl group; Ris in particular a C-alkyl group optionally substituted by a C-cycloalkyl group; Ris for example a —(CH)—C-cycloalkyl group; Ris in particular —COOH, wherein, when the fusion peptide has the formula (II), its C-terminus contains a —CO— group engaged in a peptide bond with said linker.

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Strasbourg, France

Jerôme Wagner