Pharmena Spolka Akcyjna (Pharmena S.a.)

Angionica Sp. Z O.o.

Cortria Corporation

Uniwersytet Jagiellonski

Politechnika Lodzka

Pharmena S.a.

Jerzy Gebicki

Stefan Chlopicki

Robert Bender

Eugenio A Cefali

Andrzej Marcinek

Marek K Janiak

A method of assessment of microcirculation oscillations comprises illumination of a selected location on non-hairy skin of a human subject in a resting steady condition without any blockage or stimulation of the blood flow with exciting light capable of inducing skin NADH fluorescence signal for a period of time; simultaneously with said illumination detecting, measuring and recording as a function of time the induced NADH fluorescence signal emitted from the said selected location to obtain the time course of the NADH fluorescence signal intensity in the said period of time; and computer implemented steps of: fitting of a baseline about which the NADH fluorescence signal oscillates to the said time course of the NADH fluorescence signal; and determination of a mean squared error of the deviation of the NADH fluorescence signal from the fitted baseline as a parameter of oscillatory function of the skin microcirculation.

Method of assessment of microcirculation oscillations and device therefor

A method for evaluating vascular endothelium function in a human subject comprises monitoring changes in intensity of NADH fluorescence signal emitted from skin tissue cells of an upper limb of said subject as a function of time, wherein said changes result from reactive hyperaemia caused by blocking and releasing blood flow in the same upper limb of said subject. A system for evaluating vascular endothelium function in a human subject comprises a means for illuminating a skin on an upper limb of said subject with exciting light, a means for measuring intensity of fluorescence signal emitted from the skin and recording changes of said intensity of the fluorescence signal over time; and a restriction means for blocking and releasing blood flow in the upper limb of said subject.

Method for evaluating vascular endothelium function and a system therefor

The present invention is directed to nicotinamide derivatives, and their use in treating lipoprotein abnormalities, alone or in combination with a statin.

1-methylnicotinaide derivatives and formulations of treatment of lipoprotein abnormalities

A method for the treatment or prevention of a cell or tissue damage in a living subject due to the exposure to ionizing radiation is provided, which comprises administration to said subject of a compound of formula (I) wherein R' is H, OH, CONHor COCH, R&#x2033; is H or CH, R&#x2032;&#x2033; is H or CH, and Xis a pharmaceutically acceptable counterion, in an amount sufficient to inhibit radiation-induced damage. 

Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage

1-methylnicotinamide derivatives and formulations for treatment of lipoprotein abnormalities

The invention is directed to a method for enhancing prostacyclin levels in a mammal in need thereof, wherein the method includes administering a quaternary pyridinium salt of formula (I), wherein R is NH, CH, or N(H)CHOH group, and X is pharmaceutically acceptable counterion.

Use of quaternary pyridinium salts as vasoprotective agents

The invention is directed to a method for treating hypertriglyceridemia, dyslipidemia and hypercholesterolemia by administration of a-methylnicotinamide salt.

Growing community of inventors

Lodz, Poland

Jerzy Gebicki