The University of New Mexico

Other

Jerry L Born

Dennis Eshima

Paul L Mann

Nicholas A Matwiyoff

Robert B Palmer

Buck A Rhodes

Paul T Mann

Frank O Kroh

Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance up-take of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.

Methods of radiotherapy using biomodulators

Radioactive arsenic (.sup.72 As) labelled tissue specific ligands are prepared and used in the medical imaging of malignant breast or prostate tumors.

Arsenic-72 labeled compounds for tissue specific medical imaging

Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body.

Biomodulators as universal imaging agents

Method of MRI using biomodulators

Biomodulators, in conjunction with antibodies, tumor-specific agents or conjugates thereof, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radioimages, preferably by increasing aberrant tissue signal intensity.

Enhancement of abnormal tissue uptake of antibodies, tumor-specific

Biomodulators can be administered together with an agent such as a drug or an imaging agent (specific or non-specific) structurally modified to take advantage of perturbations of cell oligosaccharide displays caused by biomodulators, to enhance images of a host, e.g., NMR-, X-ray- or radioimages, preferably by increasing aberrant tissue signal intensity. Biomodulators condition tissue to enhance or otherwise modify up-take of the drug or structurally modified imaging agent.

Growing community of inventors

Albuquerque, NM, United States of America

Jerry L Born