Battelle Memorial Institute

Other

Bright, Jessica Catherine

Jerry D Johnson

Jessica Catherine Bright

Brian L Burback

Herbert S Bresler

Michael J Brooker

Steven W Graves

Seongwon Hong

R Mark Gritz

Disclosed herein are methods of reducing muscle contraction in a diaphragm or peripheral muscle(s) of a patient sufficient to permit a surgical procedure. The methods may comprise the step of administering an oxime or pharmaceutically acceptable salt thereof to a subject in need thereof in an amount sufficient to achieve said reduced muscle contraction/neuromuscular blockade. Kits and articles of manufacture comprising a container having a label and a composition are also disclosed.

Compositions and methods for reducing muscle contraction

An automated blood or bodily fluid sampling machine for collecting, measuring and monitoring real time samples from test animals during dosing of the animals, automatically provides real-time adjustment of dosing during testing. Such automated blood or bodily fluid sampling is performed in tandem with implanted physiological monitoring devices to monitor biological and physiological parameters in restrained or freely-moving test animals. The real-time feedback provides for dosing adjustment within testing protocols.

Real time sampling, monitoring and exposure control of test animals

Growing community of inventors

Dublin, OH, United States of America

Jerry D Johnson