Pharmacia Corporation

Other

Monsanto Company

Jerry D Clark

Michael Mao

Partha Mudipalli

Jodi L Moe

Christine B Seymour

Shaun Raj Selness

Dennis K Anderson

Gopichand Yalamanchili

Win Naing

John Walker

Lisa L McDermott

Patrick H Lau

Tobin C Schilke

Kimberley C Allen

Shekhar Viswanath

John E Baldus

Jon P Lawson

Sastry A Kunda

James C Peterson

Yinong Ma

Clay Little

Ajit S Shah

Gopi Yalamanchili

Patricia S Miyake

Thomas P Fraher

Ahmad Y Sheikh

Tom Fevig

Lefteris Patelis

Joseph L Shindoll

Albert D Edney

Kimberly K Allen

Albert D Edeny

Todd Boehlow

Daniel R Dukesherer

Jason A Hanko

Dan R Dukesherer

Kimberly L Kolbert

This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I): wherein R, R, R, Y, Y, Y, Y, and Yare as defined in the specification.

Process for making substituted pyrazoles

This invention is directed generally to a process for making substituted pyrazoles, tautomers of the substituted pyrazoles, and salts of the substituted pyrazoles and tautomers. The substituted pyrazoles correspond in structure to Formula (I):wherein R, R, R, Y, Y, Y, Y, and Yare as defined in the specification.

Crystalline forms of the p38 kinase inhibitor N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl)pyrazole are provided. These crystalline forms include (a) a first anhydrous crystalline form possessing improved physical stability relative to other solid-state forms of the compound; (b) a second anhydrous crystalline form possessing unique properties relative to other solid-state forms of the compound; (c) a third anhydrous crystalline form possessing unique properties relative to other solid-state forms of the compound; and (d) solvated crystalline forms, hydrated crystalline forms, and crystalline salt forms of the compound that are useful, for example, as intermediate solid-state forms in the preparation of other crystalline forms of the compound. Also provided are combinations and pharmaceutical compositions comprising at least one of these crystalline forms, processes for preparing these crystalline forms and for preparing compositions comprising these crystalline forms, and methods for the prophylaxis and/or treatment of a p38 kinase-mediated condition comprising administering to a subject a therapeutically effective amount of at least one of these crystalline forms.

Solid-state forms of N-(2-hydroxyacetyl)-5-(4-piperidyl)-4-(4-pyrimidinyl)-3-(4-chlorophenyl) pyrazole

Synthesis of a hydrazone .beta.-keto ester by the reaction with a diazo

An adjustable shelf system for installation in combination with a non-load bearing wall which does not require penetration of the wall for support is disclosed. The adjustable shelf system is particularly well suited for use in combination with non-load bearing walls of the type supported intermediate a building foundation and an upstanding load bearing frame which includes a top track member having channels for receiving studs and prefabricated wall panels. Shelves are supported on brackets which are attached to laterally spaced, upstanding tubular support legs having a channel formed within one side wall portion. A cushion strip is confined in the channel intermediate the upstanding tubular support legs and the non-load bearing wall thereby preventing abrasive contact of the tubular support legs against the adjacent wall paneling. In a preferred embodiment, an extendable tubular member is coaxially received within the central chamber of each of the tubular support legs and projects above the tubular support legs to an elevation substantially flush with the top side surface of the top track member. Fastener means are provided for mechanicaly interconnecting the extendable tubular member to the top track member for preventing lateral displacement of the tubular support legs relative to the wall paneling.

Adjustable shelf system

Growing community of inventors

Alton, IL, United States of America

Jerry D Clark