Smithkline Corporation

Jerry Arnold Weisbach

John R Hoover

Robert M DeMarinis

David J Cooper

7.beta.-Substituted mercaptoacetamido-7.alpha.-methoxycephalosporanic acid and derivatives thereof are prepared. These compounds are antibacterial agents with improved properties.

Cephamycins as antibacterial agents

Cephalosporins with a .alpha.-amino-(ureidophenyl)acetamido substituent at position 7 are prepared by acylation of a 7-aminocephalosporin with a derivative of .alpha.-amino-p(or m)-ureidophenylacetic acid. These compounds are antibacterial agents.

Protected .alpha.-amino-.alpha.-ureido(thioureido)phenylacetic acids

.alpha.-AMINO-.alpha.-(UREIDOPHENYL)ACETAMIDOCEPHALOSPORINS AND THEIR

Alpha-amino-alpha-(ureidophenyl)acetamidocephalosporins and their

Pharmaceutical compositions of

7-Substituted mercaptoacetamido cephamycins

Novel pseudodisaccharide compounds which are related to neamine are prepared. These compounds have a mercapto group or a derivative thereof at position 3 or 4 of the glucose moiety of neamine. The compounds have antibacterial activity and have utility as intermediates to pseudotrisaccharides.

Mercaptopseudotrisaccharides

.alpha.-amino-.alpha.-(ureidophenyl)acetamidocephalosporins

Mercaptopseudodisaccharides

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Cherry Hill, NJ, United States of America

Jerry Arnold Weisbach