Other

Abbott Research B.v.

Jerry A Hall

Sandeep Dutta

Wei Liu

Andrea Best

John Powell

Duncan Casson

Mark Maginn

Hans Zinner

The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.

Antibodies against nerve growth factor (NGF) with enhanced in vivo stability

A mouthpiece for a clarinet wherein the facing over which the reed is attached and which extends around the opening in the mouthpiece is uniquely curved to vary the gap between the reed and the facing and wherein the bore, which is of a preferred length, is provided with a tapered A-frame bridge adjacent the sound baffle of the mouthpiece.

Clarinet mouthpiece

Growing community of inventors

Gurnee, IL, United States of America

Jerry A Hall