Boc, Inc.

The Boc Group, Inc.

Anaquest, Inc.

Ohmeda Pharmaceutical Products Division Inc.

Jerome R Bagley

H Kenneth Spencer

Bao-Shan Huang

Joseph William Scheblein

Bor-Sheng Lin

Nhora L Lalinde

This invention pertains to novel substituted pyrazolyl compounds useful as intravenous anesthetics represented by the Formula: ##STR1## including geometric and optically active isomeric forms, and the pharmaceutically acceptable acid addition salts thereof, wherein:

Substituted pyrazolyl compounds and methods employing such compounds

This invention pertains to novel substituted N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides useful as analgesics, and methods of administering analgesia, which comprises the systemic administration to mammals of such compounds, and pharmaceutical compositions containing such compounds, wherein the novel compounds have the general formula: ##STR1## including optically active isomeric forms, and the pharmaceutically acceptable acid addition salts thereof, wherein R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the disclosure.

N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical

This invention pertains to novel substituted N-heterocyclic-N-(4-piperidinyl)amides useful as analgesics and antagonists of opioids, wherein the compounds have the general formula: ##STR1## including optically active isomeric forms, and the pharmaceutically acceptable acid addition salts thereof, wherein:

N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions

This invention pertains to novel substituted N-heterocyclic-N-(4-piperidinyl)amides useful as analgesics and antagonists of opiolds, wherein the compounds have the general formula: ##STR1## including optically active isomeric forms, and the pharmaceutically acceptable acid addition salts thereof, wherein:

This invention pertains to novel substituted N-heterocyclic-N-(4-piperidinyl)amides useful as analgesics and antagonists of opiods, wherein the compounds have the general formula: ##STR1## including optically active isomeric forms, and the pharmaceutically acceptable acid addition salts thereof, wherein:

N-heterocyclic-N-(4-piperidinyl) amides and pharmaceutical compositions

N-heterocyclic-4-piperidiyl-amides as analgesics and antagonists of opioids with respect to such undesirable side effects as respiratory depression. Exemplary compounds have the formula ##STR1## in which formula R is a heterocyclic group, and R.sup.1 is a furanyl, thienyl, or lower alkoxy lower alkyl group, and R.sup.2 is a lower alkyl phenyl group.

N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and

N-heterocyclic-4-piperidyl-amides as analgesics and antagonists of opioids with respect to such undesirable side effects as respiratory depression. Exemplary compounds have the formula ##STR1## in which formula R is a heterocyclic group, and R.sup.1 is a furanyl, thienyl, or lower alkoxy lower alkyl group, and R.sup.2 is a lower alkyl phenyl group.

Growing community of inventors

North Plainfield, NJ, United States of America

Jerome R Bagley