Washington University

Medimmune Limited

Quretech Bio Ab

Jerome Pinkner

Scott J Hultgren

Fredrik Almqvist

James Walter Janetka

Zhenfu Han

Corinne Cusumano

Michael G Caparon

Ana L Flores-Mireles

Nils Pemberton

Veronica Aberg

Andreas Larsson

Solomon Langermann

Christine Auguste

Anders Lindgren

Ana Lidia Flores Mireles

Aaron James Leonard Lynch

Pardeep Singh

Hans Emtenas

Frederic Almqvist

The present disclosure provides a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Ring-fused thiazolino 2-pyridones, methods for preparation thereof and their use in the treatment and/or prevention of a disease involving gram-positive bacteria

The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.

Compositions and methods for the treatment and prevention of Ebp pilus-related diseases

The present invention encompasses compounds and methods for treating urinary tract infections.

Compounds and methods for treating bacterial infections

Novel amino methylated 2-pyridinones, precursors, intermediates, and derivatives; the methods for the preparation of the same; uses of the same for inhibiting pili formation in bacteria; and pharmaceutical compositions comprising these compounds are described in this application. The present compounds may be employed to inhibit biofilm formation and thereby inhibit adherence of bacteria to a host cell.

Amino methylated 2-pyridinones

Novel pyridinones and their derivatives which are effective in treating or preventing Gram-negative bacterial infections are provided. The pyridinones are stable and easily derivatized; the methods by which these derivatizations occur is described. Two regioselective and functional group tolerant methods for the synthesis of the novel pyridinones are also provided. One such synthetic method involves reacting an imine and a Meldrum's acid derivative in solution. The other synthetic method is a solid phase synthesis of the pyridinones in which an imine is prepared bound to a solid support and a Meldrum's acid derivative is reacted with the imine. Novel imine intermediates useful in the solid phase and solution methods of synthesizing the pyridionones are also described.

Pyridinones to treat and prevent bacterial infections

The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. It particularly relates to the vaccination of mammalian species with heteropolymeric protein complexes as a mechanism for stimulating production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnostics and/or as protective/treatment agents for pathogenic bacterial species. A novel vector for expressing the FimC-H complex at optimal levels is also disclosed.

Chaperone and adhesin proteins; vaccines, diagnostics and method for treating infections

Growing community of inventors

St. Louis, MO, United States of America

Jerome Pinkner