International Minerals & Chemical Corp.

The Plasmine Corporation

Jerome L Martin

Vernon V Young

Robert D Williams

David R Bright

Ralph W Emerson

A zinc complex of lysocellin is provided. The complex acts as a coccidiostat and growth-promoting agent when administered to poultry.

Zinc-lysocelling therapeutic and growth promoting agents

A process for promoting growth and feed efficiency in food producing animals is provided by administering to such animals, growth promoting amounts of certain forms of lysocellin, including the free acid and physiologically-acceptable salts thereof. Metal complexes of lysocellin can be prepared by adding the appropriate soluble metal salts to a fermentation beer containing lysocellin to thereby form an insoluble, recoverable biomass containing the desired growth-promoting metal salt complex of lysocellin for use in the process herein.

Lysocellin-containing feed efficiency-enhancing animal feed

A growth promoting and feed efficiency-enhancing amount of a lysocellin material selected from the group consisting of lysocellin, lysocellin free acid, and the physiologically acceptable salts thereof is administered to a food-producing animal selected from the group consisting of ruminants, swine and poultry in a process for promoting growth and enhancing feed efficiency of such a food-producing animal. A feed supplement for a food-producing animal, the feed supplement being capable of increasing the rate of growth of the animal when supplied in the animal's feed on a regular basis during the animal's normal growth period, and which is also capable of enhancing feed efficiency of the animal, includes a mixture of a basal feed material for a food-producing animal selected from the group consisting of ruminants, swine and poultry, and a growth rate-increasing and feed efficiency-enhancing amount of a lyoscellin material selected from the group consisting of lysocellin, lysocellin free acid, and the physiologically acceptable salts thereof.

Lysocellin-containing composition and process for promoting growth and

Manganese complexes of various monovalent and divalent polyether antibiotics are provided which act as coccidiostats and growth promoting agents when administered to food-producing animals such as cattle, sheep, swine and poultry. Soluble manganese salt is added to a fermentation beer containing the polyether antibiotics to form an insoluble, recoverable biomass containing the desired manganese antibiotic complex. This biomass, in a dried form, can be given orally to animals such as cattle, sheep, swine and poultry. The subject manganese complexes include: linear monovalent and divalent polyethers (monensin, nigericin, lasalocid, lysocellin, etc.); non-glycolic monovalent monoglycoside polyethers (septamycin, dianemycin, lenoremycin, carriomycin and antibiotic A-204); mononitrogen-containing divalent pyrrole ethers (calcimycin, X-14547, etc.); polynitrogen-containing divalent pyrrole ethers (A-23187, etc.); glycolic monovalent monoglycoside polyethers (etheromycin, etc.); other polyether antibiotics including ionomycin, aabomycin, disnerycin, duamycin, BL-580, K-41, SF-1195, M-4164A, A-32887, 30,504RP, 38,986, 44,161, 47,433, 47,434 and 47,224. The above manganese complexes are also active agents for improving cardiovascular function in animals. Purified manganese-containing antibiotic complexes can be extracted from the biomass using suitable organic solvents, followed by crystallization or precipitation of the purified complexes. The purified products can be administered as boluses, subcutaneous implants, or as injectable preparations.

Manganese-containing antibiotic agents

Zinc complexes of glycolic monovalent monoglycoside polyether antibiotics are provided for use as coccidiostats and growth-promoting agents when administered to poultry and for use as active agents for improving cardiovascular function in animals. Zinc complexes of the type disclosed can be prepared by adding soluble zinc salt to a fermentation beer containing the glycolic monovalent monoglycoside polyether antibiotic to thereby form an insoluble, recoverable biomass containing the desired zinc antibiotic complex.

Method for producing zinc etheromycin from fermentation broths

Zinc complexes of mononitrogen-containing divalent pyrrole ether antibiotics are provided. Such complexes act as coccidiostats and growth-promoting agents when administered to poultry and act as active agents for improving cardiovascular function in animals. Zinc complexes of the type disclosed can be prepared by adding soluble zinc salt to a fermentation beer containing the mononitrogen-containing pyrrole ether antibiotic to thereby form an insoluble, recoverable biomass containing the desired zinc antibiotic complex.

Zinc-containing antibiotic agents

Novel sizing compositions comprise an aqueous mixture of the reaction product of urea with selected Lewis acid, and a rosin that is modified with from about 5 to 50 percent based on the weight of the rosin, of an organic acidic compound selected from the group consisting of an .alpha.,.beta.-unsaturated organic acid, an anhydride thereof, and their mixtures. The selected Lewis acids which can be employed are sulfuryl chloride, chlorosulfonic acid, thionyl chloride, benzenesulfonyl chloride, benzenesulfonic acid, ortho- or para-toluenesulfonyl chloride, and ortho- or para-toluenesulfonic acid. Methods for making the sizing compositions and paper which is sized with the sizing compositions are also disclosed.

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Terre Haute, IN, United States of America

Jerome L Martin