William H. Rorer, Inc.

Jerome J Zalipsky

Julius Diamond

Chong M Won

William L Studt

George H Douglas

Stuart A Dodson

Dahyabhai M Patel

Novel s-triazine compounds are prepared as derivatives of the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give substituted s-triazinones and thiones respectively, of the formula ##STR1## The s-triazinones and thiones are useful derivatives in analyzing for the corresponding amidinourea or amidino thiourea precursors and also have useful pharmacological properties which make them suitable for a variety of medicinal purposes including use as antidiarrheal agents.

Triazinones

Heterocyclic alkyl s-triazine compounds are prepared from the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give respectively substituted s-triazinones and thiones of the formula ##STR1## which have pharmacological properties that render them suitable for use for a variety of medicinal purposes, including use as antidiarrheal agents, and which are also useful derivatives in analyzing for the corresponding amidinourea or amidinothiourea precursors.

Heterocyclic alkylene triazinones

Novel s-triazine compounds are prepared as derivatives of the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give substituted s-triazinones and thiones respectively, of the formula ##STR1## The s-triazinones and thiones are useful derivatives in analyzing for the corresponding amidinourea or amidinothiourea precursors and also have useful pharmacological properties which make them suitable for a variety of medicinal purposes including use as antidiarrheal agents.

This invention describes novel chemical compounds which are 1-amidino-3-phenylureas. The method of preparing these compounds and their pharmaceutical uses is also disclosed.

Amidinoureas

Triazinones from amidinoureas

Amidinoureas for lowering blood pressure

The following novel azo compounds, pharmaceutically acceptable salts and process for preparing the same are disclosed: 2-[(p-(2-pyridylsulfamoyl)phenyl)azo]hydroxybenzene; 3-[(p-(2-pyridylsulfamoyl)phenyl)azo]salicylic acid; and 5-[(p-(4-(2-pyridylanilino))-N-phenyl)azo]salicylic acid.

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Melrose Park, PA, United States of America

Jerome J Zalipsky