Cercacor Laboratories, Inc.

Masimo Laboratories, Inc.

Thermo Electron Scientific Instruments Corporation

Jerome J Workman

Christopher R Lambert

Zhaolin Wang

Alex R Zelenchuk

Emile M Bellott

Shirley J Shi

Dongsheng Bu

James J Childs

Hubert A Nienaber

Stephen R Lowry

Kathleen J Schulting

Nicholas Simon Nunn

Robert L Coleman

This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatuses, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more biologically active molecules found in skin.

Non-invasive measurement of analytes

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.

SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors

A system is provided wherein spectrometer measurements, and/or measurements from other analytical instruments, are transmitted to a processing station which determines the component substances of the sample(s) subjected to the measurements. The names of the component substances are then inserted into database search queries related to matters such as handling precautions, causes/sources of the substances, remedies and neutralizing agents for the substances, regulations related to the substances, etc. The results of the search queries are then provided to the personnel who made the measurements, preferably wirelessly and almost immediately after the measurements were made. The system therefore provides nearly immediate guidance as to what substances are present and how to handle them, which can be useful for inexperienced personnel in hazardous response, contraband detection, industrial process control, and other situations.

Spectral measurement with assisted data analysis

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Madison, WI, United States of America

Jerome J Workman