University of Virginia Patent Foundation

Other

James Madison University

Jerome Ferrance

James P Landers

Matthew R Begley

Michael H Jones

Boris Gelmont

Tatiana Globus

Jian Wen

Jennifer Monahan-Dian

Aaron Moyer

Marcel Utz

Alexei Bykhovski

Brian H Augustine

Sushil Shrinivasan

Kelley A Wolfe

Michael C Breadmore

W Christopher Hughes

Amir Jazaery

Pamela E Norris

Joy M Polefrone

Igor Sizov

Ling Huang

Scott Barker

Mary E Power

Certain exemplary embodiments can provide a method, which comprises causing a determination to be made that a body fluid sample is from a patient with cancer. The determination can be made via analyzing the body fluid sample by sub-THz resonance spectroscopy with absorption determinations being made at a plurality of frequencies between 0.05 and 1.0 THz to show a presence of specific Micro-RNAs as cancer related molecules in the body fluid.

Micro-RNA based diagnoses of ovarian and other cancers via sub-terahertz vibrational spectroscopy

Biological cells or spores are analyzed by using enhanced THz coupling to molecules by depositing a test material in a channel of a microfluidic chip using near field sensing of sub-THz radiation from the molecules. The THz radiation is enhanced by transmitting THz radiation through slots in the chip, illuminating molecules of the test material with the enhanced THz radiation transmitted through the slots. A spectroscopic signature of the test material is generated, and a database of signatures of materials is generated. The test material is identified by comparing the signature of the test material with signatures of materials in the database.

Terahertz spectroscopy characterization with high spectral and spatial resolution for biological and chemical sensing and method of use

The present invention relates to the fabrication of a grafted, UV photo-polymerized silica-based monolithic column and the use of such column for the extraction of DNA. In one embodiment, a method is provided for fabricating a silica-based monolithic column, wherein a vessel is filled with a polymerization mixture that is formed into monolithic solid phase for DNA extraction through in situ photo-polymerization.

DNA extraction using a photo-polymerized monolith in a capillary

In an example, an apparatus, such as a microfluidic assembly, can include or can include using a channel including a valve seat, a valve film configured to adjust position with respect to the valve seat, and a first electrode configured to actuate the valve film electrostatically to adjust the position of the valve film to control a flow of a fluid in the channel laterally across the valve seat, the flow in a direction substantially parallel to the film.

Electrostatic actuation for management of flow in micro-total analysis systems (&#x3bc;-TAS) and related method thereof

The invention relates to sensors for detecting chemical and biological material and for chemical actuation. In particular, the sensors of the present invention incorporates membranes or beams that are deformable in the presence of chemical adsorption on its surface. The sensor of the present invention contains a polymeric membrane or beam () that is clamped at least at two opposing ends () and ().

Microdevices for chemical sensing and chemical actuation

The present invention relates to microfluidic devices, and in particular, flow management in such devices. In particular, the present invention provides an electrostatic valve for flow manipulation in a microfluidic device. The valve of the present invention sits on a valve seat in a microchannel and deflects away from the valve seat by electrostatic actuation to assume an opened configuration to allow fluid flow.

Grafted photo-polymerized monolithic column

The present invention is directed to novel device comprising a sol-gel filled microchannel and methods for purifying nucleic acids from biological samples. In one embodiment shown in FIG., the microfluidic device () comprises a base () with a microchannel () formed in the interior of base (), wherein said microchannel () is filled with a sol-gel matrix and in fluid communication with an inlet port () and outlet port () wherein inlet port () and outlet port () are formed on the exterior surface () of base (). The device may be further provided with additional components to allow for analytical analysis of the purified nucleic acid sequences.

Apparatus and method for the purification of nucleic acids

The present invention is directed to improved microdevices and methods of manufacturing such devices. More particularly the present invention is directed to the use of a compound having the general structure (formula (I)): wherein R is selected from the group consisting of C-Calkyl, C-Calkenyl, C-Calkynyl, C-Ccycloalkyl, and C-Caryl for bonding silica based substrates to plastic substrates or to other silica based substrates. In addition the polymer can be used to coat microchannels to enhance the physical properties of the microdevice 

Hybrid polymers for functional tuning of microfluidic device surfaces

Growing community of inventors

Charlottesville, VA, United States of America

Jerome Ferrance