Beth Israel Deaconess Medical Center, Inc.

New England Deaconess Hospital Corporation

Jerome E Groopman

Hava Karsenty Avraham

Shalom Avraham

Sally Cowley

Novel methods of detecting and treating breast cancer are described.

Methods of detection and treatment of breast cancer

The invention contemplates the novel neural cell protein marker RR/B, cDNA encoding RR/B, nucleic acid probes for detection of mRNA encoding RR/B, synthetic polypeptides whose sequences correspond to a portion of RR/B and have a molecular weight equal to less than that of RR/B antibodies specific for RR/B, and methods for detection of RR/B.

Neural cell protein marker RR/B and DNA encoding the same

A class of murine monoclonal antibodies that is capable of stimulating megakaryocytopoiesis in vitro has been raised against human megakaryocytic cells. The monoclonal antibody BAH-1 specifically recognizes and demonstrates agonist activity against the c-Mpl receptor on the megakaryocytic cell surface. In therapeutic applications, the BAH-1 and M4 monoclonal antibodies identified to date and similar antibodies (or active portions and chimeric combinations thereof) can stimulate proliferation of primary bone marrow megakaryocytes. Thus, the antibodies of the invention can be used to prepare a composition for treating, e.g., thrombocytopenia. A typical composition comprises a therapeutically effective amount of the BAH-1 monoclonal antibody in association with a pharmaceutically acceptable carrier vehicle.

Agonist murine monoclonal antibody as a stimulant for

The invention contemplates the novel neural cell protein marker RR/B, cDNA encoding RR/B, nucleic acid probes for detection of mRNA encoding RR/B, synthetic polypeptides whose sequences correspond to a portion of RR/B and have a molecular weight equal to less than that of RR/B, and methods for detection of RR/B.

Neural cell protein marker RR/B and DNA encoding same

Differentiated megakaryocytes produced by introducing an activated oncogene into blast-megakaryocytes is disclosed. Also disclosed are novel megakaryocyte differentiation factors and platelets obtained from the differentiated megakaryocytes.

Growing community of inventors

Brookline, MA, United States of America

Jerome E Groopman