Other

Centre National De La Recherche Scientifique

Wisconsin Alumni Research Foundation

The Scripps Research Institute

Université Grenoble Alpes

Jérôme Dupuy

Eric Arthur Johnson

Raymond C Stevens

William Howard Tepp

Guangyun Lin

Paul Stenmark

Franck Fieschi

Pal Erik Gustav Stenmark

Christine Hajjar

William H Tepp

Mickaël Cherrier

Mark Joseph Jacobson

The present invention relates to novel NADPH oxidase proteins, or Nox, the use thereof, the method of preparation thereof and the method for identification thereof.

NADPH oxidase proteins

A NADPH oxidase (Nox) protein includes a domain including 3 to 7 transmembrane helices, and an amino acid sequence including at least 2 bis-histidyl motifs, wherein each of the bis-histidyl motifs consists of 2 histidine residues separated by 12, 13 or 14 amino acid residues. The Nox protein may be produced by a method that includes solubilizing a solution of cells expressing the Nox protein using a detergent from the maltoside family to suspend the Nox protein in the solution.

A novel subtype of type A botulinum neurotoxin (BoNT/A) is disclosed in the application. Methods to purify the neurotoxin as well as uses thereof are also disclosed.

[object Object]

Growing community of inventors

Saint Quentin sur Isère, France

Jérôme Dupuy