Lifecell Corporation

Other

Cerapedics, Inc.

Jerome Connor

Qing-Qing Qiu

Aaron M Barere

Wendell Sun

Rick T Owens

Stephen A Livesey

Sangwook Park

Laura M Currie

Mark Hayzlett

Christopher T Wagner

John R Harper

Jason Park

Michael Brian Burnett

Katherine Suzanne Davis

Nolan Chase Hannigan

Tristan Stuart Barnes

Doug Millard

Qiu Qing-Qing

Jessica Stufflet

Christopher Todd Wagner

Jevon Nyemscek

Nicolas Roscioli

The present disclosure provides tissue products produced from adipose tissues, as well as methods for producing such tissue products. The tissue products can include acellular extracellular matrices. In addition, the present disclosure provides systems and methods for using such products.

Adipose tissue matrices

A method of coating a peptide or protein useful for improving the cellular activity related to bone growth on an inorganic particle comprises the steps of freezing the residual liquid present on uncoated and or coated inorganic particles, and drying the uncoated or coated inorganic particles after freezing the residual liquid, the drying comprising causing the frozen residual liquid to sublime under vacuum. Further disclosed embodiments of the invention include further processes for forming inorganic particles coated with a peptide or protein useful for improving cellular activity related to bone growth and medical devices comprising the coated particles.

Processes for coating inorganic particles with a peptide or protein useful for improving cellular activity related to bone growth

The present disclosure relates generally to methods of treatment of tissue prior to implantation. In one aspect, the methods of treatment include washing adipose tissue with detergents to improve the viability of adipose cells for implantation and/or to increase the amount of viable adipose cells per volume of tissue for implantation.

Methods for improved treatment of adipose tissue

The present disclosure provides a variety of methods and compositions useful for making, sterilizing, and preserving tissues. The disclosure also features the acellular tissue matrices made by the methods.

Method for preparing collagen-based materials

The present disclosure provides devices and methods for harvesting and processing tissue from patients for grafting. The devices can include a tissue collection chamber for ascetically collecting, processing, and/or re-implanting adipose tissue.

Device for harvesting, processing and transferring adipose tissue

Systems and methods for sterilization of tissue are provided.

Systems and methods for tissue sterilization

The invention features a dry platelet composition and methods of making and using the freeze-dried platelet composition.

Dry platelet composition

Systems for sterilization of demineralized bone matrices are provided.

Systems and methods for sterilization of bone or bone components

Device for harvesting, processing, and transferring adipose tissue

Method for sterilizing an acellular tissue matrix

A red blood cell storage composition includes a composition of red blood cells and biochemistry altering reagents, the biochemistry altering reagents being present at a concentration so as to reduce the percent hemolysis of the red blood cells during the freeze-thaw cycle below that of the percent hemolysis of the red blood cells in the absence the biochemistry altering reagents. The red blood cell storage composition preferably includes reagents selected from: modifiers of glycolytic/metabolic components, modifiers of antioxidant potential, effectors of intracellular ionic distribution, modifiers of membrane fluidity, modifiers of cytoskeletal structure, effectors of the cyclooxygenase second messenger pathway, effectors of the lipoxygenase second messenger pathway, effectors of the hexose monophosphate second messenger pathway, effectors of the phosphorylation second messenger pathway, modifiers of specific messenger molecules, and combinations thereof.

Composition for cryopreservation comprising nicotinamide, glycerol and red blood cells

The present disclosure provides a variety of methods and compositions (e.g., solutions) useful for making, sterilizing, and preserving tissues (e.g., acellular tissue matrices). The disclosure also features the acellular tissue matrices made by the methods, which matrices can be used for a variety of applications such as, but not limited to, treating an injury to, or repairing, a large number of tissues and/or organs (e.g., e.g., fascia, bones, and/or cartilage) in a mammal (e.g., a human).

Acellular tissue matrix preservation solution

This invention provides a method for prolonging the preservation of human blood platelets at reduced temperatures. The method uses an inhibitor system that enables blood platelets to retain their functional integrity during storage. In addition, the inhibitor system prevents the generation of cytokines in the platelet preparation during storage at both 22&deg; C. and 4&deg; C. This is accomplished by interrupting normal platelet function during storage, so as to help keep platelets from activating and losing their shape. Before using the platelets in a transfusion, they are returned to their normal functional level by washing the inhibitor system away from the platelets.

Growing community of inventors

Doylestown, PA, United States of America

Jerome Connor