Centre National De La Recherche Scientifique

Université Paris—sud

Université Paris-Saclay

Centre National De La Recherche Scientifique (Cnrs) Etablissement Public

Jérôme Bignon

Joanna Bakala

Jean-Daniel Brion

Samir Messaoudi

Abdallah Hamze

Jean-Yves Lallemand

Joëlle Dubois

Mouad Alami

Catherine Guillou

Olivier Provot

Pierre Jean-Paul Potier

Maxim Egorov

Jian-Miao Liu

Bernard Delpech

Pascal Collin

Mouâd Alami

Jean-Paul Pierre Potier

Michel Benechie

Johanna Bakala

Jean-François Peyrat

Anne Giraud

Mohamed-Ali Soussi

Denyse Herlem

Emile Benechie

Joanna Bakala-Wdzieczak

Françoise Khuong-Huu

Guy Jean Marie Potier, Legal Representative

Marie-Claude Denise Michèle Zelveyan, Legal Representative

Yves Fromes

Catherine Marie Germaine Magnan, Legal Representative

Odette Drion, Legal Representative

Françoise Lawrence

Odile Thoison

Nathalie Cheviron

Joanna Elzbieta Bakala

Francoise Lawrence

Maria Concepcion Achab

Maria Achab

Liu Jian-Miao

The present invention relates to the design of novel molecules, referred to as 'multi-target' molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDACs) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the 'multi-target' molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one &#x201c;multi-target&#x201d; molecule, and the use of such compositions in the treatment of cancer.

'Multi-target' compounds with inhibitory activity towards histone deacetylases and tubulin polymerisation, for use in the treatment of cancer

The invention relates to compounds which are inhibitors of the polymerization of tubulin, to the methods for the production thereof, and to the uses of same.

Cytotoxic compounds which are inhibitors of the polymerisation of tubulin

This invention relates to the cosmetic use of at least one compound of formula (I) wherein

Cosmetic use of at least the natural tetrapeptide Ac-Ser-Asp-Lys-Pro or one of its analogs as a skin restructuring agent

The invention relates to a compound of the formula (I) in which: R, Rand Rare independently a methoxy group optionally substituted by one or more fluorine atoms; Ris a hydrogen atom; Rand Rare identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.

Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization

The cosmetic use of at least one compound of formula (I) wherein: Ais the radical corresponding to D- or L-Ser; Ais the radical corresponding to D- or L-Asp or Glu; Ais the radical corresponding to D- or L-Lys, Arg or Orn; Ais the radical corresponding to D- or L-Pro; R, R, Rare such as defined in the claims, as agent for controlling hair loss. 

Agent for slowing hair loss and/or stimulating hair growth

The invention relates to pyranone derivatives of general formula (I), wherein X is chlorine, bromine or iodine and Rand Ris independently a hydrogen atom, an alkyl, cycloalkyl or alkylene, linear or branched group containing 1-20 carbon atoms, optionally substituted by a hydroxyl, amino, ether or halogen group, or Rand Rform together a cycle of 5, 6, 7 or 8 members which is optionally substituted by a hydroxyl, amino, ether or halogen group including isomers, enantiomers, diastereoisomers and the mixtures thereof. A method for preparing the inventive derivatives and the therapeutic use thereof, in particular for treating cancer, are also disclosed.

Pyranone derivatives useful for treating cancer

The present invention relates to the use of a compound of formula I: 

Angiogenic agents and their uses

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Le Val Saint Germain, France

Jérôme Bignon